Carbon nanotubes as magnetic nanocarriers in the targeted chemotherapy

Funding: 499 075,00 PLN

Duration: 2013 – 2016

Abstract:

The scope of the project is to study an employment of Fe-nanoparticle-encapsulated multi-wall carbon nanotubes (Fe@MWCNTs) and their chemically modified analogues towards magnetically targeted Drug Delivery Systems (t-DDS). The proposed drug-vehicles could demonstrate properties surpassing other commonly explored nanomaterials (e.g. SPIONs), namely controllable magnetic nanotube core content, negligible cytotoxicity and capability of anchoring various drug molecules (5FU, purpurins etc.) via non-covalent and covalent bonding. Description of the final drug-nanotube hybrids will cover their comprehensive analysis including morphology, physicochemical characteristics, steerability by magnetic field, physically- and chemically-induced drug-release profile and biological activity against healthy and cancer cells. The experiments should answer the questions of the remote ‘steerability’ and selectivity of the drug-nanotube hybrids and lead to in vivo experiments.

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